The CEO of THQ has confirmed that Blob 2 is in development. The first episode was a great surprise for the Wii.

Released late 2008 on Wii, de Blob was presented as an instrument of high quality, both in graphics and in gameplay that is both simple and innovative. To recall, Blob was invented by amateurs before being assigned to the studio Blue Tongue Entertainment.
Since the soft was well past, the development of a sequel had already been raised by THQ More than a year. During its financial conference, the CEO of THQ, has formalized the development of Blob 2 on Nintendo Wii. The details remain fuzzy about it yet, but we learned that its release is anticipated during the fiscal year 2011, between April 2010 and March 2011.